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Drug and Alcohol Dependence Subcortical white matter (WM), thalamus, cerebellar cortex, and corpus callosum were most affected. Higher cigarette pack-years related to smaller volumes in several subcortical regions. Magnetic resonance imaging studies of cigarette smoking-related effects on human brain structure have primarily employed voxel-based morphometry, and the most consistently reported finding was smaller volumes or lower density in anterior frontal regions and the insula. Much less is known about the effects of smoking on subcortical regions. We compared smokers and non-smokers on regional subcortical volumes, and predicted that smokers demonstrate greater age-related volume loss across subcortical regions than non-smokers. Non-smokers (n = 43) and smokers (n = 40), 22–70 years of age, completed a 4 T MRI study. Bilateral total subcortical lobar white matter (WM) and subcortical nuclei volumes were quantitated via FreeSurfer. In smokers, associations between smoking severity measures and subcortical volumes were examined. Smokers demonstrated greater age-related volume loss than non-smokers in the bilateral subcortical lobar WM, thalamus, and cerebellar cortex, as well as in the corpus callosum and subdivisions. In smokers, higher pack-years were associated with smaller volumes of the bilateral amygdala, nucleus accumbens, total corpus callosum and subcortical WM. Results provide novel evidence that chronic smoking in adults is associated with accelerated age-related volume loss in subcortical WM and GM nuclei.

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Cal Poly to be smoke-free - | San Luis Obispo and Santa Barbara Area News Cal Poly will become a smoke-free campus before the start of the new school year. Starting September 1, smoking will no longer be allowed on campus. Signs are posted on the sides of ash trays advising the campus community of the upcoming change. "I actually just heard right now, so yeah, I'm very surprised. Kind of shocked but hey, maybe it's good for all of us," said Cal Poly student Mateo Cuellar. The new policy is in response to a systemwide CSU Executive Order issued in April. Chancellor Timothy White directed that all 23 campuses be smoke and tobacco-free September 1st. Right now, there are 73 designated smoking areas at Cal Poly. Student Ellie Vutova says too many students smoke.

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