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Drug and Alcohol Dependence Subcortical white matter (WM), thalamus, cerebellar cortex, and corpus callosum were most affected. Higher cigarette pack-years related to smaller volumes in several subcortical regions. Magnetic resonance imaging studies of cigarette smoking-related effects on human brain structure have primarily employed voxel-based morphometry, and the most consistently reported finding was smaller volumes or lower density in anterior frontal regions and the insula. Much less is known about the effects of smoking on subcortical regions. We compared smokers and non-smokers on regional subcortical volumes, and predicted that smokers demonstrate greater age-related volume loss across subcortical regions than non-smokers. Non-smokers (n = 43) and smokers (n = 40), 22–70 years of age, completed a 4 T MRI study. Bilateral total subcortical lobar white matter (WM) and subcortical nuclei volumes were quantitated via FreeSurfer. In smokers, associations between smoking severity measures and subcortical volumes were examined. Smokers demonstrated greater age-related volume loss than non-smokers in the bilateral subcortical lobar WM, thalamus, and cerebellar cortex, as well as in the corpus callosum and subdivisions. In smokers, higher pack-years were associated with smaller volumes of the bilateral amygdala, nucleus accumbens, total corpus callosum and subcortical WM. Results provide novel evidence that chronic smoking in adults is associated with accelerated age-related volume loss in subcortical WM and GM nuclei.

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Facebook also said it plans to add 1,000 new workers to review ads on the platform. Over at Twitter, one of the focal points as Congress and others focus on Russia’s alleged use of social media to influence the election is the prevalence of bots on the platform , which can be commandeered to disseminate disingenuous information. If you thought the days of Big Tobacco ads on mainstream media were over, think again. At least temporarily. From November, the makers of brands including Marlboro and Camel have been forced by a court to buy prime-time TV spots and newspaper ads to settle a lawsuit brought nearly two decades ago by the U.S. Department of Justice over misleading statements the industry had made about the health effects of cigarettes, The Wall Street Journal reports. The ads won’t display graphic images but instead will present stark black-and-white text statements stating how tobacco companies “intentionally designed cigarettes to make them more addictive,” while another will say “more people die every year from smoking than from murder, AIDS, suicide, drugs, car crashes, and alcohol, combined.” Amazingly, there’s no requirement these ads run on any digital channels, where many young, impressionable people who might be considering taking up smoking tend to consume a lot of their media. “I think [tobacco companies are] getting off kind of lightly,” said John Boiler, co-founder of 72andSunny, an agency that does work for the antitobacco nonprofit Truth Campaign. CMO Today’s Alexandra Bruell reports: Anheuser-Busch InBev has consolidated its global media account with four agencies, down from eight. Dentsu Aegis Network wins the large U.S. account from incumbent Mediacom, which is owned by WPP.

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